SHP-2 Mediates C-type Lectin Receptors-induced Syk Activation and Anti-fungal TH17 Responses
نویسندگان
چکیده
Zihou Deng1, Shixin Ma1, Hao Zhou2, Aiping Zang1, Yiyuan Fang1, Tiantian Li1, Huanjing Shi1, Mei Liu1, Min Du1, Patricia R. Taylor3, Helen H. Zhu4, Jiangye Chen5, Guangxun Meng1, Fubin Li6, Changbin Chen1, Yan Zhang1, Xin-Ming Jia7, Xin Lin8, Xiaoming Zhang1, Eric Pearlman3, Xiaoxia Li2, Gen-Sheng Feng9, and Hui Xiao1,*,¶ 1Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China
منابع مشابه
Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection
Innate immune cells detect pathogens via pattern recognition receptors (PRRs), which signal for initiation of immune responses to infection. Studies with Dectin-1, a PRR for fungi, have defined a novel innate signaling pathway involving Syk kinase and the adaptor CARD9, which is critical for inducing Th17 responses to fungal infection. We show that another C-type lectin, Dectin-2, also signals ...
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عنوان ژورنال:
دوره 16 شماره
صفحات -
تاریخ انتشار 2015